Wednesday 21 Oct
Levante UD vs Athletic Club
Levante (17th) are only safe on goal difference and face an Athletic Club side that is only 2 points clear of them.
Friday 23 Oct
VfB Stuttgart vs Borussia Mönchengladbach
Stuttgart (13th) are only 1 point above the playoff spot and face a winless Monchengladbach side in 18th.
Deportivo Alavés vs Málaga CF
Last-place Malaga travel to 7th place Alaves needing a win to close the 3-point gap to safety.
Ipswich Town FC vs Nottingham Forest FC
19th place Nottingham Forest are 1 point from safety and need a result against 10th place Ipswich to climb out of the bottom three.
Torino FC vs AC Monza
14th place Monza are 3 points ahead of the relegation zone and looking to pull further away from danger.
Stade Brestois 29 vs OGC Nice
13th place Nice are 4 points above the relegation zone, while 10th place Brest look to secure their mid-table position.
Saturday 24 Oct
SS Lazio vs Parma Calcio 1913
2nd place Lazio are level on points with the leaders and face 19th place Parma who are stuck in the drop zone.
Coventry City FC vs Fulham FC
A crucial relegation six-pointer between 17th place Coventry and 18th place Fulham who are separated by just 1 point.
Arsenal FC vs Everton FC
2nd place Arsenal must win to keep pressure on Manchester City as they currently sit 3 points off the top.
Aston Villa FC vs Manchester City FC
League leaders Manchester City look to extend their 3-point lead at the top against 12th place Aston Villa.
Borussia Dortmund vs Eintracht Frankfurt
2nd place Dortmund are level on points with the leaders and cannot afford to drop points against 11th place Frankfurt.
Rayo Vallecano de Madrid vs Elche CF
A vital bottom-half clash as 18th place Elche look to jump out of the relegation zone against 13th place Rayo Vallecano.
FC Augsburg vs 1. FC Union Berlin
17th place Union Berlin are currently in the relegation zone and face an Augsburg side only 3 points ahead of them.
Valencia CF vs Villarreal CF
19th place Valencia are 1 point deep in the relegation zone and need a result to climb toward safety.
SSC Napoli vs AS Roma
9th place Napoli are 5 points behind the Champions League cutoff, making this a must-win against 3rd place Roma.
Chelsea FC vs Tottenham Hotspur FC
4th place Chelsea aim to protect their Champions League spot against a Tottenham side hovering 1 point above the relegation zone.
SC Paderborn 07 vs Hamburger SV
Paderborn (16th) currently occupy the relegation playoff spot and face 9th place HSV who are chasing the top four.
Real Racing Club de Santander vs RCD Espanyol de Barcelona
Both 15th place Espanyol and 16th place Racing Santander are just 1 point above the La Liga relegation zone.
Toulouse FC vs ES Troyes AC
17th place Troyes are in the relegation zone and face a Toulouse side that is 5 points clear of the bottom three.
Club Atlético de Madrid vs RC Deportivo La Coruña
2nd place Atletico Madrid must win to stay within 5 points of Barcelona in the La Liga title race.
1. FC Köln vs FC Schalke 04
Schalke (15th) are level on points with the playoff spot and face a Koln side that is only 2 points ahead of them.
RB Leipzig vs SV 07 Elversberg
6th place Elversberg and 7th place Leipzig are both within 4 points of the Champions League spots in the Bundesliga.
Como 1907 vs US Sassuolo Calcio
5th place Como sit just 1 point behind AC Milan for the final Champions League qualification spot.
1. FSV Mainz 05 vs SV Werder Bremen
5th place Mainz are 3 points behind the top four and must win to stay in contention for Champions League football.
Cagliari Calcio vs Bologna FC 1909
15th place Bologna are only 1 point clear of the relegation zone, placing heavy stakes on their visit to 7th place Cagliari.
Sunday 25 Oct
FC Barcelona vs Real Madrid CF
A massive El Clasico where 3rd place Real Madrid can pull within 3 points of league leaders Barcelona in the title race.
Paris Saint-Germain FC vs Olympique Lyonnais
A direct clash for the top spot as 1st place Lyon and 2nd place PSG are currently tied on 14 points.
SC Freiburg vs FC Bayern München
1st place Bayern Munich travel to 3rd place Freiburg with only 1 point separating the two sides at the top of the table.
AS Monaco FC vs Lille OSC
A high-stakes fixture as 4th place Lille and 5th place Monaco are both level on points with the league leaders.
FC Internazionale Milano vs ACF Fiorentina
1st place Inter Milan look to maintain their lead while Fiorentina (18th) sit in the relegation zone.
Genoa CFC vs Venezia FC
17th place Genoa sit just 1 point above the drop zone and face bottom-of-the-table Venezia.
Liverpool FC vs Brighton & Hove Albion FC
5th place Liverpool look to close the 4-point gap on 3rd place Brighton to secure their standing in the Champions League race.
Udinese Calcio vs AC Milan
4th place AC Milan need a win to stay in the top four while Udinese (16th) sit just outside the relegation zone.
Olympique de Marseille vs Le Havre AC
Bottom-placed Le Havre are 4 points from safety and desperately need points against 9th place Marseille.
AJ Auxerre vs Le Mans FC
16th place Le Mans are currently in the drop zone and look to overtake Auxerre who sit only 3 points above them.
RC Celta de Vigo vs Real Betis Balompié
8th place Celta Vigo are within 3 points of the Champions League spots currently occupied by 4th place Real Betis.
Real Sociedad de Fútbol vs Levante UD
5th place Real Sociedad are only 3 points off the top four, while Levante (17th) are fighting to stay out of the drop zone.
Stade Rennais FC 1901 vs RC Strasbourg Alsace
6th place Rennes are only 1 point away from the Champions League spots, while Strasbourg (14th) are 3 points from relegation.
TSG 1899 Hoffenheim vs Bayer 04 Leverkusen
4th place Leverkusen look to stay in the Champions League spots, while Hoffenheim (14th) are only 1 point clear of the playoff spot.
Sunderland AFC vs Leeds United FC
Bottom-place Sunderland are 2 points from safety and face 7th place Leeds who are chasing the top five.
Hull City AFC vs Brentford FC
A mid-table battle where 6th place Brentford and 9th place Hull are both within 3-4 points of the Champions League cutoff.
Atalanta BC vs Frosinone Calcio
6th place Frosinone are only 2 points away from the top four, making this a significant match for the European race.
Manchester United FC vs AFC Bournemouth
Manchester United (13th) are surprisingly only 2 points above the relegation zone, making this match against 15th place Bournemouth vital.
US Lecce vs Juventus FC
8th place Juventus are 4 points behind the Champions League cutoff and cannot afford to slip up against 12th place Lecce.
Angers SCO vs FC Lorient
15th place Angers sit only 1 point above the Ligue 1 relegation zone and face 7th place Lorient.
Crystal Palace FC vs Newcastle United FC
14th place Crystal Palace are currently only 2 points clear of the Premier League drop zone.
Athletic Club vs Getafe CF
Both 11th place Athletic and 14th place Getafe are within 2 points of the bottom three in a crowded lower table.
Monday 26 Oct
Sevilla FC vs CA Osasuna
6th place Sevilla are 5 points behind the top four, representing the outer limit of the Champions League race.